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MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer

K. S. Wagner-Larsen, N. Lura, A. Gulati, S. Ryste, E. Hodneland, K. E. Fasmer, K. Woie, B. I. Bertelsen, Ø. Salvesen, M. K. Halle, N. Smit, C. Krakstad, and I. S. Haldorsen

Abstract

Effective diagnostic tools for prompt identification of high-risk locally advanced cervical cancer (LACC) patients are needed to facilitate early, individualized treatment. The aim of this work was to assess temporal changes in tumor radiomics (delta radiomics) from T2-weighted imaging (T2WI) during concurrent chemoradiotherapy (CCRT) in LACC patients, and their association with progression-free survival (PFS). Furthermore, to develop, validate, and compare delta- and pretreatment radiomic signatures for prognostic modeling.

K. S. Wagner-Larsen, N. Lura, A. Gulati, S. Ryste, E. Hodneland, K. E. Fasmer, K. Woie, B. I. Bertelsen, Ø. Salvesen, M. K. Halle, N. Smit, C. Krakstad, and I. S. Haldorsen, "MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer," BMC cancer, vol. 25, p. 122, 2025. doi:10.1186/s12885-025-13509-1
[BibTeX]

Effective diagnostic tools for prompt identification of high-risk locally advanced cervical cancer (LACC) patients are needed to facilitate early, individualized treatment. The aim of this work was to assess temporal changes in tumor radiomics (delta radiomics) from T2-weighted imaging (T2WI) during concurrent chemoradiotherapy (CCRT) in LACC patients, and their association with progression-free survival (PFS). Furthermore, to develop, validate, and compare delta- and pretreatment radiomic signatures for prognostic modeling.
@article{wagner2025mri,
title = {MRI delta radiomics during chemoradiotherapy for prognostication in locally advanced cervical cancer},
author = {Wagner-Larsen, Kari S and Lura, Njål and Gulati, Ankush and Ryste, Stian and Hodneland, Erlend and Fasmer, Kristine E and Woie, Kathrine and Bertelsen, Bjørn I and Salvesen, Øyvind and Halle, Mari K and Smit, Noeska and Krakstad, Camilla and Haldorsen, Ingfrid S},
year = 2025,
journal = {BMC cancer},
volume = 25,
pages = 122,
doi = {10.1186/s12885-025-13509-1},
url = {https://bmccancer.biomedcentral.com/articles/10.1186/s12885-025-13509-1},
abstract = {Effective diagnostic tools for prompt identification of high-risk locally advanced cervical cancer (LACC) patients are needed to facilitate early, individualized treatment. The aim of this work was to assess temporal changes in tumor radiomics (delta radiomics) from T2-weighted imaging (T2WI) during concurrent chemoradiotherapy (CCRT) in LACC patients, and their association with progression-free survival (PFS). Furthermore, to develop, validate, and compare delta- and pretreatment radiomic signatures for prognostic modeling.},
images = {images/wagner2025mri.png},
thumbnails = {images/wagner2025mri.png},
pdf = {pdfs/wagner2025mri.pdf}
}
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